Intrathecal colistin for treatment of Pseudomonas aeruginosa ventriculitis: report of a case with successful outcome

Polymyxin B and polymyxin E (colistin) are the two polymyxins used in clinical practice. Colistin is a polymyxin-type antibiotic, disrupting the structure of Gram-negative organisms’ cell membranes, rarely used parenterally because it has nephrotoxic side effects. The polymyxins are active against selected Gram-negative bacteria, including Acinetobacter species, Pseudomonas aeruginosa, Klebsiella species and Enterobacter species [1]. We report a case of multidrugresistant P. aeruginosa ventriculitis treated successfully with intrathecal colistin.